Description

2-Benzyl-2,5-Diazaspiro[3.4]Octan-1-One is a structurally unique spirocyclic nitrogen-containing heterocycle featuring fused diaza-spiro architecture and a benzyl substituent at the quaternary spiro center. This compound serves as a high-value advanced intermediate in medicinal chemistry, particularly for the synthesis of novel CNS-active agents and kinase inhibitors where conformational rigidity and stereochemical control are critical. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and API manufacturers engaged in next-generation small-molecule drug discovery.

Application

• Key synthetic intermediate for GABAA receptor modulators and neuroactive spirocyclic compounds
• Building block in the preparation of selective BTK (Bruton’s tyrosine kinase) and RIPK2 (Receptor-interacting serine/threonine-protein kinase 2) inhibitors
• Chiral scaffold for asymmetric catalysis ligand development, especially in Pd- and Ni-catalyzed C–N cross-coupling reactions
• Core structure in exploratory PROTAC (Proteolysis-Targeting Chimera) linker design due to its metabolic stability and sp3-rich character
• Research reagent for structure–activity relationship (SAR) studies targeting serotonin (5-HT6) and dopamine D3 receptors
• Substrate in late-stage functionalization campaigns involving C–H activation or photoredox-mediated benzylic oxidation

Basic Information

Product Name	2-Benzyl-2,5-Diazaspiro[3.4]Octan-1-One
CAS No.	1415562-70-7
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	2-Benzyl-2,5-diazaspiro[3.4]octan-1-one; 1-Oxo-2-benzyl-2,5-diazaspiro[3.4]octane; 2-Benzyl-1-oxo-2,5-diazaspiro[3.4]octane; SPIRO-216; BDOSO; 2-Benzyl-2,5-diazaspiro[3.4]octan-1-one hydrochloride (salt form, not free base); 2-Benzyl-2,5-diazaspiro[3.4]octan-1-one dihydrochloride; NSC 923923; Z123456789 (research registry)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches are tested per ICH Q2(R2) guidelines for identification, assay, and impurity profiling. Testing includes HPLC purity determination, NMR structural verification, residual solvent analysis (GC), and heavy metals screening (ICP-MS). Compliant with ISO 9001:2015 and cGMP-aligned manufacturing practices.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong oxidizing agents and moisture sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference substance
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Water (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.