Description

4-(1-(2-(tert-Butoxycarbonyl)Hydrazinyl)Ethyl)Benzoic Acid is a structurally defined, Boc-protected hydrazide derivative featuring a benzoic acid moiety and a chiral ethyl-linked hydrazine functionality. It serves as a critical advanced intermediate in the synthesis of targeted therapeutics—particularly peptidomimetics, protease inhibitors, and conformationally constrained bioactive molecules—where precise steric and electronic control is essential. Pharmaceutical R&D laboratories, contract development and manufacturing organizations (CDMOs), and medicinal chemistry teams rely on this compound for solid-phase and solution-phase peptide coupling, late-stage functionalization, and scaffold diversification under mild deprotection conditions.

Application

• Key building block for the synthesis of serine protease inhibitors (e.g., thrombin, factor Xa inhibitors)
• Intermediate in the preparation of Boc-protected hydrazide-containing prodrugs and linker-payload systems for antibody-drug conjugates (ADCs)
• Substrate for palladium-catalyzed cross-coupling reactions to access biaryl-hydrazide scaffolds in kinase inhibitor discovery
• Chiral synthon for asymmetric synthesis of α-hydrazino acid derivatives used in GPCR-targeted compounds
• Reagent in the development of pH-responsive hydrogels and stimuli-responsive drug delivery carriers
• Component in high-throughput combinatorial libraries for fragment-based lead generation (FBLG)

Basic Information

Product Name	4-(1-(2-(tert-Butoxycarbonyl)Hydrazinyl)Ethyl)Benzoic Acid
CAS No.	1415560-36-9
Molecular Formula	C14H20N2O4
Molecular Weight	280.32 g/mol
Synonyms	Boc-NH-NH-CH(CH3)C6H4COOH; 4-[1-[(2-tert-Butoxycarbonyl)hydrazino]ethyl]benzoic acid; 4-(1-((Boc)hydrazino)ethyl)benzoic acid; tert-Butyl (1-(4-carboxyphenyl)ethyl)hydrazinecarboxylate; 4-(1-(2-(tert-Butoxycarbonyl)hydrazino)ethyl)benzoic acid; Boc-Hydrazinoethylbenzoic acid; 4-(1-(2-((tert-Butoxy)carbonyl)hydrazinyl)ethyl)benzoic acid; N-(1-(4-Carboxyphenyl)ethyl)-2-methylprop-2-enoylhydrazide (tautomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent purity and identity criteria aligned with ACS Reagent Grade and Pharmaceutical Intermediate (API Intermediate) specifications, including full spectral verification (FT-IR, 1H NMR), residual solvent analysis (GC), heavy metals (ICP-MS), and water content (Karl Fischer titration). Testing is performed in ISO 17025-accredited laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its hygroscopic nature, minimize exposure to ambient humidity; use desiccant storage or nitrogen-purged containers for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identity (IR)	Conforms to reference standard
Identity (1H NMR)	Conforms to reference spectrum in DMSO-d6
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.