Description

7-Bromo-4,4-Difluoro-3,4-Dihydronaphthalen-1(2H)-One is a high-value, multi-functional fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on a partially saturated naphthalene core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro moiety can enhance metabolic stability and bioavailability.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system and halogen atoms.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to introduce halogen atoms for modulating lipophilicity and binding affinity.
• Cross-Coupling Reactions: The bromine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse chemical libraries.
• Fluorine Chemistry Research: A valuable substrate for studying the effects of gem-difluoro groups on the physical and chemical properties of organic molecules.

Basic Information

Product Name	7-Bromo-4,4-Difluoro-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	1415108-26-7
Molecular Formula	C₁₀H₇BrF₂O
Molecular Weight	261.07 g/mol
Synonyms	7-Bromo-4,4-difluoro-1,2,3,4-tetrahydronaphthalen-1-one; 7-Bromo-4,4-difluoro-3,4-dihydro-1(2H)-naphthalenone; 1(2H)-Naphthalenone, 7-bromo-4,4-difluoro-3,4-dihydro-; 4,4-Difluoro-7-bromo-3,4-dihydro-1(2H)-naphthalenone; 7-Bromo-4,4-difluoro-1-tetralone
EINECS	Contact for details

Quality Control

Our 7-Bromo-4,4-Difluoro-3,4-Dihydronaphthalen-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent batch-to-batch quality suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.