Description

2-Chloro-4-(1-Naphthalenyl)-Quinazoline is a high-value, functionalized quinazoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique molecular architecture, featuring a fused naphthalene ring system and a reactive chloro substituent, makes it an essential building block for constructing complex heterocyclic frameworks. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other biologically active quinazoline-based molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its heterocyclic core for bioactivity.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the reactive chlorine atom.
• Academic & Contract Research: A valuable reagent for methodological development and discovery chemistry in university and CRO laboratory settings.

Basic Information

Product Name	2-Chloro-4-(1-Naphthalenyl)-Quinazoline
CAS No.	1413376-86-9
Molecular Formula	C18H11ClN2
Molecular Weight	290.75 g/mol
Synonyms	4-(Naphthalen-1-yl)-2-chloroquinazoline; 2-Chloro-4-(naphthalen-1-yl)quinazoline; 2-Chloro-4-(1-naphthyl)quinazoline; Quinazoline, 2-chloro-4-(1-naphthalenyl)-; 1413376-86-9; 2-Chloro-4-(α-naphthyl)quinazoline
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-(1-Naphthalenyl)-Quinazoline is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.