Description

5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 1,1-Dibromo-, 5-(1,1-Dimethylethyl) Ester, (6S)- is a high-value, stereochemically defined spirocyclic building block designed for advanced synthetic chemistry. This compound is critical for pharmaceutical and agrochemical research, serving as a key chiral intermediate in the synthesis of complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and life science industries seeking to introduce a constrained, functionalized azaspiro scaffold into their target structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides where the spirocyclic structure can confer unique biological properties and stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed in constructing molecular probes for studying enzyme function and biological pathways due to its rigid, three-dimensional geometry.
• Material Science Research: Potential building block for specialty polymers and advanced organic materials requiring specific spatial architectures.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex molecules for clients.

Basic Information

Item	Details
Product Name	5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 1,1-Dibromo-, 5-(1,1-Dimethylethyl) Ester, (6S)-
CAS No.	1412903-77-5
Molecular Formula	C13H19Br2NO4
Molecular Weight	421.10 g/mol
Synonyms	(6S)-5-(tert-Butyl) 1,1-dibromo-5-azaspiro[2.4]heptane-5,6-dicarboxylate; (6S)-5-(tert-Butoxycarbonyl)-1,1-dibromo-5-azaspiro[2.4]heptane-6-carboxylic acid; 1,1-Dibromo-5-azaspiro[2.4]heptane-5,6-dicarboxylic acid 5-(1,1-dimethylethyl) ester (6S)-; tert-Butyl (6S)-1,1-dibromo-6-(methoxycarbonyl)-5-azaspiro[2.4]heptane-5-carboxylate (enol form); Spirocyclic dibromo ester; (6S)-Azaspiroheptane dibromo diester; CAS 1412903-77-5
EINECS	Contact for details

Quality Control

Every batch of 5-Azaspiro[2.4]Heptane-5,6-Dicarboxylic Acid, 1,1-Dibromo-, 5-(1,1-Dimethylethyl) Ester, (6S)- is produced and tested under a strict quality management system. Our products undergo rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity consistent with advanced intermediate standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.