Description

(S)-3,3-Difluorocyclopentanamine Hydrochloride is a high-purity chiral amine building block of significant interest in modern pharmaceutical research and development. Its value lies in the unique stereochemistry and the presence of fluorine atoms, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of drug candidates. This compound is primarily needed by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, leveraging fluorine's ability to enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Chemical Biology Probe Synthesis: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Advanced Material Research: Investigated as a monomer or functional additive in the development of specialty polymers and advanced materials with tailored properties.

Basic Information

Product Name	(S)-3,3-Difluorocyclopentanamine Hydrochloride
CAS No.	1408148-48-0
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	(1S)-3,3-Difluorocyclopentanamine hydrochloride; (S)-3,3-Difluorocyclopentylamine hydrochloride; (S)-3,3-Difluorocyclopentan-1-amine hydrochloride; (S)-3,3-Difluorocyclopentylammonium chloride; 1408148-48-0; (S)-3,3-Difluorocyclopentanamine HCl; (S)-3,3-Difluorocyclopentamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3,3-Difluorocyclopentanamine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of the pharmaceutical industry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.