Description

3,3-Difluoro-1-Methylcyclobutanamine Hydrochloride is a high-purity, fluorinated amine salt building block of significant interest in advanced organic synthesis. Its value lies in the unique structural and electronic properties imparted by the difluorocyclobutane core, which is crucial for modulating the physicochemical characteristics of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting metabolic diseases, CNS disorders, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorinated cyclobutane moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral amines or ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into specialty polymers and advanced materials to alter thermal stability, solubility, and surface properties.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	3,3-Difluoro-1-Methylcyclobutanamine Hydrochloride
CAS No.	1408076-03-8
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	1-Methyl-3,3-difluorocyclobutanamine hydrochloride; 3,3-Difluoro-1-methylcyclobutan-1-amine hydrochloride; 3,3-Difluoro-N-methylcyclobutanamine HCl; 3,3-Difluoro-1-methylcyclobutanamine HCl salt; (3,3-Difluoro-1-methylcyclobutyl)amine hydrochloride; 1408076-03-8; 1-Methyl-3,3-difluorocyclobutan-1-amine HCl
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-1-Methylcyclobutanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.