Description

trans-3-Methylsulfonylcyclobutylamine Hydrochloride is a high-purity, synthetically valuable building block used in advanced pharmaceutical research and development. This compound is critical for medicinal chemists seeking to introduce a rigid, polar sulfonyl-substituted cyclobutylamine scaffold into novel drug candidates. It is primarily utilized by R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of potential therapeutic agents, particularly in areas requiring precise stereochemistry and functional group manipulation.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of small molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the trans-3-methylsulfonylcyclobutylamine moiety on potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a potential precursor or core structure in the design of inhibitors for enzymes like proteases, due to the hydrogen-bonding capability of the sulfonamide and amine groups.
• Chemical Biology Probes: Can be incorporated into chemical probes for studying biological processes and target engagement within cells.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and pre-clinical scale-up.

Basic Information

Product Name	trans-3-Methylsulfonylcyclobutylamine Hydrochloride
CAS No.	1408075-97-7
Molecular Formula	C5H12ClNO2S
Molecular Weight	185.67 g/mol
Synonyms	trans-3-(Methylsulfonyl)cyclobutanamine hydrochloride; (1r,3r)-3-(Methylsulfonyl)cyclobutan-1-amine hydrochloride; 3-(Methylsulfonyl)cyclobutanamine hydrochloride (trans-); Cyclobutanamine, 3-(methylsulfonyl)-, hydrochloride, (1r,3r)-; trans-3-Aminocyclobutyl methyl sulfone hydrochloride; (trans)-3-Methylsulfonylcyclobutylamine HCl
EINECS	Contact for details

Quality Control

Our trans-3-Methylsulfonylcyclobutylamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Chiral Purity (Chiral HPLC)	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.