Description

trans-3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride is a high-value, advanced pharmaceutical intermediate characterized by its unique cyclobutane scaffold and trifluoromethyl group. This compound is essential for medicinal chemistry research and development, offering significant potential for modulating the pharmacokinetic and metabolic properties of novel drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule therapeutics targeting a range of diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical space and optimize drug-like properties.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new crop protection agents and pesticides.
• Proteolysis Targeting Chimera (PROTAC) Linker Component: Potential use in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tools for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	trans-3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride
CAS No.	1408075-16-0
Molecular Formula	C6H9F3N2O • HCl
Molecular Weight	218.60 g/mol (Free base: 182.14 g/mol)
Synonyms	trans-3-Amino-1-(trifluoromethyl)cyclobutan-1-ol HCl; 1-(Trifluoromethyl)-3-aminocyclobutanol Hydrochloride (trans); (1r,3r)-3-Amino-1-(trifluoromethyl)cyclobutan-1-ol Hydrochloride; (1s,3s)-3-Amino-1-(trifluoromethyl)cyclobutan-1-ol Hydrochloride; trans-3-Amino-α,α,α-trifluoromethylcyclobutylmethanol Hydrochloride; 3-Amino-1-(trifluoromethyl)cyclobutan-1-ol Hydrochloride (trans); 1408075-16-0
EINECS	Contact for details

Quality Control

Our trans-3-Amino-1-(Trifluoromethyl)Cyclobutan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.