Description

Methyl 2-Boc-2-Aza-Spiro[3.3]Heptane-6-Carboxylate CAS NO 1408074-81-6 is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and Boc-protected amine structure. This compound is critical for medicinal chemists as a versatile building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and other therapeutic areas. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new chemical entities and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex molecules for drug discovery and development programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a component in the linker or warhead sections of bifunctional molecules designed for targeted protein degradation.
• CNS Drug Research: The spiro[3.3]heptane scaffold is valuable for creating novel compounds targeting neurological disorders due to its potential to improve blood-brain barrier penetration and metabolic stability.
• Medicinal Chemistry Scaffold: Serves as a rigid, three-dimensional core structure for constructing diverse compound libraries for high-throughput screening.
• Peptidomimetic Synthesis: Employed in the design and synthesis of peptide analogs to enhance stability and bioavailability.
• Chemical Biology Probes: Used in the creation of tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	Methyl 2-Boc-2-Aza-Spiro[3.3]Heptane-6-Carboxylate
CAS No.	1408074-81-6
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-2-azaspiro[3.3]heptane-6-carboxylic acid methyl ester; Methyl 2-[(tert-butoxycarbonyl)amino]-2-azaspiro[3.3]heptane-6-carboxylate; 2-Azaspiro[3.3]heptane-6-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester; 2-Boc-2-Aza-Spiro[3.3]heptane-6-carboxylic Acid Methyl Ester; 2-Aza-spiro[3.3]heptane-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester; Boc-2-Aza-Spiro[3.3]heptane-6-COOMe
EINECS	Contact for details

Quality Control

Our Methyl 2-Boc-2-Aza-Spiro[3.3]Heptane-6-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.