Description

cis-3-Methoxycyclobutanamine Hydrochloride is a high-purity, synthetically derived organic salt of significant interest in advanced pharmaceutical research and development. Its unique cyclobutane scaffold, functionalized with methoxy and amine groups, makes it a valuable and versatile chiral building block for constructing complex molecular architectures. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors. Its stable hydrochloride salt form facilitates handling and integration into multi-step synthetic sequences aimed at discovering new therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical space.
• Process Chemistry & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for candidate drugs.
• Asymmetric Synthesis: Acts as a key starting material or reagent in catalytic asymmetric transformations to introduce stereochemical complexity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial batches.

Basic Information

Product Name	cis-3-Methoxycyclobutanamine Hydrochloride
CAS No.	1408074-54-3
Molecular Formula	C6H14ClNO
Molecular Weight	151.63 g/mol
Synonyms	cis-3-Methoxycyclobutan-1-amine hydrochloride; (1s,3s)-3-Methoxycyclobutan-1-amine hydrochloride; 3-Methoxycyclobutanamine HCl (cis-); Cyclobutanamine, 3-methoxy-, hydrochloride, (1s,3s)-; 1408074-54-3; cis-3-Methoxycyclobutylamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of cis-3-Methoxycyclobutanamine Hydrochloride is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.