Description

tert-Butyl 7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting complex disease pathways. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring spirocyclic or constrained heterocyclic motifs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential Active Pharmaceutical Ingredients (APIs).
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glue Development: The reactive handles and specific stereochemistry make it valuable for constructing bifunctional degraders in targeted protein degradation therapies.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	1408074-46-3
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	7-Hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; tert-Butyl 7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; 2-Azaspiro[3.4]octane-2-carboxylic acid, 7-hydroxy-5-oxa-, 1,1-dimethylethyl ester; 1408074-46-3; BOC-Protected 7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.