Description

3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(9R)-10,11-Dihydrocinchonan9-Yl]Amino]-3-Cyclobutene-1,2-Dione is a sophisticated, high-value chemical intermediate featuring a unique cyclobutenedione core functionalized with trifluoromethylphenyl and cinchona alkaloid-derived amine groups. This compound matters for its role as a key building block in the synthesis of advanced pharmaceutical candidates and chiral catalysts, offering significant potential in asymmetric synthesis and medicinal chemistry research. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical sectors focused on developing novel therapeutics and high-performance catalytic systems.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring chiral specificity.
• Chiral Catalyst/Ligand Precursor: The cinchonan moiety makes it a valuable starting material for developing novel asymmetric catalysts used in enantioselective synthesis.
• Advanced Material Research: Used in the development of specialty polymers or organic electronic materials where its rigid, fluorinated structure can impart unique properties.
• Agrochemical Synthesis: Acts as a building block for creating new active ingredients with enhanced biological activity and environmental stability.
• Academic & Industrial R&D: Employed in research programs exploring new chemical reactions, catalysis, and structure-activity relationships (SAR).
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for complex molecules in pilot plants and kilo labs.

Basic Information

Product Name	3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(9R)-10,11-Dihydrocinchonan9-Yl]Amino]-3-Cyclobutene-1,2-Dione
CAS No.	1407166-64-6
Molecular Formula	C33H27F6N3O2
Molecular Weight	611.58 g/mol
Synonyms	3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-(((9R)-10,11-dihydrocinchonan-9-yl)amino)cyclobut-3-ene-1,2-dione; 3-[(3,5-Bis(trifluoromethyl)phenyl)amino]-4-{[(9R)-10,11-dihydrocinchonan-9-yl]amino}-3-cyclobutene-1,2-dione; 3-Amino-4-((9R)-10,11-dihydrocinchonan-9-ylamino)-3-cyclobutene-1,2-dione derivative; Cinchona-Alkylamino Cyclobutenedione Trifluoromethyl Derivative; (R)-3-((3,5-Bis(trifluoromethyl)phenyl)amino)-4-((10,11-dihydrocinchonan-9-yl)amino)cyclobut-3-ene-1,2-dione; CAS 1407166-64-6
EINECS	Contact for details

Quality Control

Our 3-[[3,5-Bis(Trifluoromethyl)Phenyl]Amino]-4-[[(9R)-10,11-Dihydrocinchonan9-Yl]Amino]-3-Cyclobutene-1,2-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and/or hygroscopic; therefore, handling under an inert atmosphere and desiccated conditions is recommended for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.