Description

6-Bromo-5-Fluoro-3,4-Dihydro-1H-Quinolin-2-One is a high-purity, advanced pharmaceutical intermediate with a defined heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of novel, complex active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic research. Pharmaceutical R&D teams, fine chemical manufacturers, and contract research organizations (CROs) need this precise chemical scaffold to develop next-generation drug candidates with improved efficacy and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a core structural motif in the research and development of novel small-molecule drugs.
• Oncology Research: Used as a key precursor in synthesizing potential kinase inhibitors and other targeted cancer therapies.
• CNS Drug Discovery: Employed in building blocks for compounds targeting neurological disorders.
• Agrochemical Synthesis: Can be utilized in developing advanced intermediates for new generation herbicides or fungicides.
• Material Science Research: Acts as a specialty monomer or precursor for functionalized polymers and advanced organic materials.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis and scale-up projects under cGMP guidelines.

Basic Information

Item	Details
Product Name	6-Bromo-5-Fluoro-3,4-Dihydro-1H-Quinolin-2-One
CAS No.	1404367-69-6
Molecular Formula	C9H7BrFNO
Molecular Weight	244.06 g/mol
Synonyms	6-Bromo-5-fluoro-3,4-dihydro-2(1H)-quinolinone; 6-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one; 5-Fluoro-6-bromo-3,4-dihydro-1H-quinolin-2-one; 1404367-69-6; 6-Br-5-F-DHQO; 2-Quinolinone, 6-bromo-5-fluoro-3,4-dihydro-; 6-Bromo-5-fluoro-3,4-dihydroquinolin-2(1H)-one
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Fluoro-3,4-Dihydro-1H-Quinolin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP standards for advanced pharmaceutical applications, ensuring traceability and regulatory compliance for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.