Description

8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-One is a high-purity, advanced pharmaceutical intermediate featuring a unique bridged bicyclic structure with a fluorine substituent. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers seeking to build complex molecular architectures with high stereochemical control.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those with tropane alkaloid-like structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Neurological Drug Development: Serves as a precursor for potential therapeutics targeting neurological disorders, leveraging the fluorine atom for metabolic stability and the bridged scaffold for receptor binding.
• Process Chemistry & Scale-Up: Employed in route scouting and process development for the commercial manufacturing of new chemical entities (NCEs).
• Academic Research: Used in universities and research institutes for studying synthetic methodologies and the properties of fluorinated heterocycles.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-One
CAS No.	1404196-37-7
Molecular Formula	C₁₂H₁₉FNO₃
Molecular Weight	244.28 g/mol
Synonyms	8-[(tert-Butoxycarbonyl)-2-fluoro-8-azabicyclo[3.2.1]octan-3-one; 2-Fluoro-8-azabicyclo[3.2.1]octan-3-one, 8-(1,1-dimethylethyl) ester; 8-Boc-2-fluoro-8-azabicyclo[3.2.1]octan-3-one; tert-Butyl 2-fluoro-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate; 8-Azabicyclo[3.2.1]octan-3-one, 8-[(1,1-dimethylethoxy)carbonyl]-2-fluoro-; Fluorinated Tropane Derivative; Bicyclic Fluorinated Building Block
EINECS	Contact for details

Quality Control

Our 8-Boc-2-Fluoro-8-Aza-Bicyclo[3.2.1]Octan-3-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.