Description

6-Amino-3-Aza-Bicyclo[4.1.0]Heptane-3-Carboxylic Acid tert-Butyl Ester is a high-value, protected bicyclic amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its rigid, constrained scaffold and functional groups make it an essential intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including protease inhibitors and other biologically relevant molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor research.
• Peptidomimetics: Used to introduce constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and binding affinity.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereochemically defined active ingredients for crop protection.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme function and biological pathways.
• Catalyst Ligand Development: The bicyclic structure can be utilized to develop novel chiral ligands for asymmetric catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	6-Amino-3-Aza-Bicyclo[4.1.0]Heptane-3-Carboxylic Acid tert-Butyl Ester
CAS No.	1403767-24-7
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 6-amino-3-azabicyclo[4.1.0]heptane-3-carboxylate; 3-Azabicyclo[4.1.0]heptane-3-carboxylic acid, 6-amino-, 1,1-dimethylethyl ester; 6-Amino-3-azabicyclo[4.1.0]heptane-3-carboxylic acid 1,1-dimethylethyl ester; Bicyclo[4.1.0]heptane, 6-amino-3-aza-, 3-carboxylic acid tert-butyl ester; Protected 3-Azabicyclo[4.1.0]heptane-6-amine; (1R,6S)-6-Amino-3-azabicyclo[4.1.0]heptane-3-carboxylic acid tert-butyl ester (for specific stereoisomer).
EINECS	Contact for details

Quality Control

Our 6-Amino-3-Aza-Bicyclo[4.1.0]Heptane-3-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. The original container should be allowed to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.