Description

1-(3-Azetidinyl)-3,3-Difluoro-Pyrrolidine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique azetidine-pyrrolidine scaffold with difluoro substitution. This compound matters for its critical role as a key building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. Pharmaceutical R&D teams and fine chemical manufacturers need it for developing next-generation therapeutics, particularly in areas like central nervous system (CNS) disorders and enzyme inhibition.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a core scaffold in the development of protease inhibitors due to its nitrogen-rich heterocyclic structure.
• Kinase Inhibitor Development: Employed in the synthesis of potential kinase inhibitors for oncology and inflammatory disease targets.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects at CDMOs (Contract Development and Manufacturing Organizations).

Basic Information

Product Name	1-(3-Azetidinyl)-3,3-Difluoro-Pyrrolidine Dihydrochloride
CAS No.	1403766-97-1
Molecular Formula	C7H13Cl2F2N2
Molecular Weight	231.10 g/mol
Synonyms	1-(Azetidin-3-yl)-3,3-difluoropyrrolidine dihydrochloride; 3,3-Difluoro-1-(3-azetidinyl)pyrrolidine dihydrochloride; 3-(3,3-Difluoropyrrolidin-1-yl)azetidine dihydrochloride; Azetidine, 3-(3,3-difluoro-1-pyrrolidinyl)-, dihydrochloride; 1403766-97-1; 1-(3-Azetidinyl)-3,3-difluoropyrrolidine HCl
EINECS	Contact for details

Quality Control

Our 1-(3-Azetidinyl)-3,3-Difluoro-Pyrrolidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.