Description

Bicyclo[1.1.1]Pentan-1-Ylhydrazinedihydrochloride is a high-purity, specialized organic building block of significant interest in advanced pharmaceutical and agrochemical research. Its unique, highly strained bicyclo[1.1.1]pentane (BCP) scaffold is prized for its ability to act as a bioisostere for aromatic rings and alkynes, offering improved metabolic stability and physicochemical properties in drug candidates. This compound is primarily utilized by medicinal chemists and R&D scientists in the pharmaceutical, biotechnology, and crop protection industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates targeting a wide range of therapeutic areas, including CNS disorders, oncology, and metabolic diseases.
• Bioisostere Incorporation: Used to replace traditional aromatic or alkyne groups in lead optimization to enhance potency, solubility, and metabolic profile.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides with potentially new modes of action.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-ligand interactions.
• Material Science Exploration: Investigated for the creation of novel polymers and advanced materials with unique structural properties derived from the BCP core.
• Peptidomimetics: Facilitates the development of constrained peptide analogs with improved bioavailability and target selectivity.

Basic Information

Product Name	Bicyclo[1.1.1]Pentan-1-Ylhydrazinedihydrochloride
CAS No.	1403746-38-2
Molecular Formula	C5H12Cl2N2
Molecular Weight	171.07 g/mol
Synonyms	1-Bicyclo[1.1.1]pentanylhydrazine dihydrochloride; BCP-Hydrazine dihydrochloride; [1.1.1]Propellane, 1-hydrazino-, dihydrochloride; Bicyclo[1.1.1]pentan-1-amine, N-amino-, dihydrochloride; 1-Aminobicyclo[1.1.1]pentane-1-carbohydrazide dihydrochloride (tautomer); 1403746-38-2; BCP-NHNH2·2HCl
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]Pentan-1-Ylhydrazinedihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP principles where applicable, ensuring reliable consistency and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.