Description

1-[(4S)-4-tert-Butyl-4,5-Dihydro-2-Oxazolyl]Isoquinoline is a high-value, chiral heterocyclic compound featuring a fused isoquinoline and oxazoline scaffold. This molecule is of significant interest as a sophisticated building block and ligand precursor in advanced organic synthesis and catalysis research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the development of novel active ingredients and catalytic processes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Catalysis Ligand Precursor: Serves as a precursor for chiral oxazoline-based ligands used in transition metal catalysis for enantioselective C-C and C-X bond formations.
• Advanced Material Research: Investigated as a component in the synthesis of organic semiconductors and luminescent materials due to its rigid, conjugated structure.
• Agrochemical Synthesis: Employed in the discovery and synthesis of novel, high-performance crop protection agents with specific stereochemical requirements.
• Academic & Industrial R&D: Used in methodological studies and as a reference standard in chemical research focused on nitrogen-containing heterocycles.

Basic Information

Item	Details
Product Name	1-[(4S)-4-tert-Butyl-4,5-Dihydro-2-Oxazolyl]Isoquinoline
CAS No.	1402851-52-8
Molecular Formula	C₁₆H₁₈N₂O
Molecular Weight	254.33 g/mol
Synonyms	(S)-4-(tert-Butyl)-2-(isoquinolin-1-yl)-4,5-dihydrooxazole; (S)-1-(4-(tert-Butyl)-4,5-dihydrooxazol-2-yl)isoquinoline; (4S)-4-tert-Butyl-2-(1-isoquinolyl)-4,5-dihydro-1,3-oxazole; (S)-4-tert-Butyl-2-(isoquinolin-1-yl)-2-oxazoline; Chiral Oxazoline-Isoquinoline Ligand Precursor; 1-[(4S)-4-tert-Butyl-4,5-dihydrooxazol-2-yl]isoquinoline
EINECS	Contact for details

Quality Control

Every batch of 1-[(4S)-4-tert-Butyl-4,5-Dihydro-2-Oxazolyl]Isoquinoline is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and enantiomeric excess meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA), including results from chiral HPLC, NMR, and mass spectrometry, is supplied with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.