Description

5-Cyclopropyl-2-Fluoropyridine-3-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical and agrochemical research and development. Its unique structure, featuring a cyclopropyl ring and a fluorine atom on the pyridine core, makes it a critical intermediate for constructing novel active compounds with enhanced metabolic stability and binding affinity. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of advanced drug candidates, particularly in therapeutic areas like oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluoropyridine moiety.
• Material Science: Serves as a precursor for advanced organic materials, including ligands for catalysis and functionalized polymers.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes and activity-based protein profiling (ABPP) reagents.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	5-Cyclopropyl-2-Fluoropyridine-3-Carboxylic Acid
CAS No.	1402664-71-4
Molecular Formula	C9H8FNO2
Molecular Weight	181.16 g/mol
Synonyms	2-Fluoro-5-cyclopropylnicotinic acid; 3-Pyridinecarboxylic acid, 5-cyclopropyl-2-fluoro-; 5-Cyclopropyl-2-fluoropyridine-3-carboxylic acid; 5-Cyclopropyl-2-fluoro-3-pyridinecarboxylic acid; 2-Fluoro-5-cyclopropyl-3-pyridinecarboxylic acid; 1402664-71-4; 5-Cyclopropyl-2-fluoronicotinic acid
EINECS	Contact for details

Quality Control

Our 5-Cyclopropyl-2-Fluoropyridine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications from research to commercial-scale cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Purity (HPLC, Area %)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.