Description

tert-Butyl (4-Bromo-2-Hydroxybenzyl)Carbamate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated hydroxybenzyl and carbamate-protected amine structure. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on creating new drug candidates, particularly in areas requiring halogenated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: The carbamate protecting group makes it valuable for the controlled introduction of amine functionalities in peptide-like molecules.
• Ligand and Inhibitor Development: Employed in the research and development of enzyme inhibitors and receptor ligands, leveraging the bromine atom for further functionalization via cross-coupling reactions.
• Fine Chemical Production: Serves as a precursor in the custom synthesis of specialty chemicals for agrochemical and material science applications.

Basic Information

Product Name	tert-Butyl (4-Bromo-2-Hydroxybenzyl)Carbamate
CAS No.	1402664-46-3
Molecular Formula	C12H16BrNO3
Molecular Weight	302.17 g/mol
Synonyms	Boc-4-Bromo-2-hydroxybenzylamine; N-Boc-4-Bromo-2-hydroxybenzylamine; tert-Butyl N-(4-bromo-2-hydroxybenzyl)carbamate; 4-Bromo-2-hydroxybenzylcarbamic acid tert-butyl ester; (4-Bromo-2-hydroxybenzyl)carbamic acid tert-butyl ester; 1-[(tert-Butoxycarbonyl)amino]methyl]-5-bromo-2-hydroxybenzene; 2-Hydroxy-4-bromobenzyl carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (4-Bromo-2-Hydroxybenzyl)Carbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.