Description

tert-Butyl 4-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethyl-substituted piperidine scaffold. This compound matters for its critical role in modern medicinal chemistry, where the trifluoromethyl group is prized for its ability to enhance metabolic stability, lipophilicity, and bioavailability in drug candidates. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of small molecule drugs, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the metabolically stable trifluoromethyl group.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors, leveraging the piperidine amine functionality.
• Agrochemical Active Ingredient Development: Employed in the research of novel herbicides and pesticides where the CF3 group can improve efficacy.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring high-purity, complex heterocyclic amines.

Basic Information

Product Name	tert-Butyl 4-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate Hydrochloride
CAS No.	1402047-77-1
Molecular Formula	C11H20ClF3N2O2
Molecular Weight	304.74 g/mol
Synonyms	1-Boc-4-Amino-4-(trifluoromethyl)piperidine hydrochloride; 4-Amino-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester hydrochloride; tert-Butyl 4-amino-4-(trifluoromethyl)-1-piperidinecarboxylate hydrochloride; 1-(tert-Butoxycarbonyl)-4-amino-4-(trifluoromethyl)piperidine HCl; 4-(Trifluoromethyl)-4-aminopiperidine-1-carboxylic acid tert-butyl ester hydrochloride; 4-Amino-1-Boc-4-(trifluoromethyl)piperidine hydrochloride; 1-N-Boc-4-amino-4-trifluoromethylpiperidine hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-4-(Trifluoromethyl)Piperidine-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.