Description

H-Ser(Tbu)-Obzl.Hcl is a protected serine derivative, specifically an amino acid building block, widely used in peptide synthesis. Its primary value lies in providing a chemically stable intermediate that allows for selective deprotection during complex peptide chain assembly, ensuring high yields and purity in the final product. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who are developing novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the stepwise construction of peptide sequences on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for producing peptides and peptide conjugates in solution.
• Pharmaceutical Intermediate: Serves as a critical raw material in the research and development of active pharmaceutical ingredients (APIs) for peptide drugs.
• Bioconjugation: Facilitates the site-specific modification of peptides and proteins for creating targeted drug delivery systems or diagnostic probes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Industrial Research: A fundamental reagent for studying peptide structure, function, and metabolism in biochemical research.

Basic Information

Product Name	H-Ser(Tbu)-Obzl.Hcl
CAS No.	1401668-21-0
Molecular Formula	C14H22ClNO4
Molecular Weight	303.78 g/mol
Synonyms	H-Ser(OtBu)-OBzl HCl; O-tert-Butyl-L-serine benzyl ester hydrochloride; L-Serine, O-(1,1-dimethylethyl)-, benzyl ester, hydrochloride (1:1); Benzyl O-tert-butyl-L-serinate hydrochloride; Fmoc-Ser(tBu)-OH benzyl ester hydrochloride (related precursor); Ser(OtBu)-OBzl.HCl; Protected Serine Benzyl Ester Hydrochloride; Amino Acid Building Block Ser(tBu)-OBzl HCl
EINECS	Contact for details

Quality Control

Our H-Ser(Tbu)-Obzl.Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -15.0° (c=1 in MeOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.