Description

3-(2-Fluoroethoxy)Azetidine Trifluoroacetate Salt is a high-purity, non-racemic chiral building block and intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its azetidine ring, a saturated four-membered nitrogen heterocycle that serves as a valuable bioisostere in medicinal chemistry for improving the metabolic stability and potency of drug candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic profiles of lead compounds.
• Process Chemistry & Scale-up: Serves as a building block in the development and optimization of scalable synthetic routes for potential APIs under Good Manufacturing Practice (GMP) conditions.
• Ligand & Catalyst Development: Can be employed in the design of novel ligands for asymmetric catalysis or as a component in organocatalysts.
• Chemical Biology Probes: Useful for creating labeled compounds or probes to study biological pathways and enzyme functions.

Basic Information

Product Name	3-(2-Fluoroethoxy)Azetidine Trifluoroacetate Salt
CAS No.	1401425-82-8
Molecular Formula	C7H11F4NO3
Molecular Weight	233.16 g/mol
Synonyms	3-(2-Fluoroethoxy)azetidine trifluoroacetate; Azetidine, 3-(2-fluoroethoxy)-, trifluoroacetate (1:1); 3-(2-Fluoroethoxy)azetidine TFA salt; 3-(2-Fluoroethoxy)-azetidine trifluoroacetic acid salt; 3-(β-Fluoroethoxy)azetidine trifluoroacetate; 1-(2-Fluoroethyl)-3-azetidinol trifluoroacetate (tautomeric form); CAS 1401425-82-8
EINECS	Contact for details

Quality Control

Our 3-(2-Fluoroethoxy)Azetidine Trifluoroacetate Salt is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.