Description

2-Chloro-5,6,7,8-Tetrahydro-[1,7]Naphthyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant synthetic utility. This compound is valued for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Used in the research and synthesis of novel herbicides, fungicides, or insecticides that utilize naphthyridine-based chemistry.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and target validation.
• Fine Chemical Synthesis: Acts as a specialized building block for creating complex molecules in custom synthesis and contract manufacturing.

Basic Information

Product Name	2-Chloro-5,6,7,8-Tetrahydro-[1,7]Naphthyridine Hydrochloride
CAS No.	1401034-59-0
Molecular Formula	C8H10ClN2•HCl
Molecular Weight	207.09 g/mol
Synonyms	2-Chloro-5,6,7,8-tetrahydro-1,7-naphthyridine hydrochloride; 2-Chloro-5,6,7,8-tetrahydro[1,7]naphthyridine HCl; 1,7-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride; 2-Chloro-5,6,7,8-tetrahydro-1,7-naphthyridine monohydrochloride; 1401034-59-0 (CAS); Tetrahydro-naphthyridine hydrochloride derivative.
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,6,7,8-Tetrahydro-[1,7]Naphthyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring material that meets stringent internal standards, with the capability to align with cGMP guidelines as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.