Description

2-[(9R)-9-(Pyridin-2-Yl)-6-Oxaspiro[4.5]Decan-9-Yl]Acetonitrile is a high-value, chiral nitrile intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a sophisticated building block in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals. Pharmaceutical R&D teams and specialty chemical manufacturers need this material to construct complex molecular architectures, particularly for candidates targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing novel nitrogen-containing ligands used in transition metal catalysis.
• Agrochemical Research: Employed in the discovery of new, more selective pesticides and herbicides that require complex, functionalized spirocyclic structures.
• Material Science Precursor: Investigated for the synthesis of specialty polymers and advanced organic materials with specific electronic or structural properties.
• Academic & Contract Research: Used in university and CRO laboratories for methodological development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	2-[(9R)-9-(Pyridin-2-Yl)-6-Oxaspiro[4.5]Decan-9-Yl]Acetonitrile
CAS No.	1401031-38-6
Molecular Formula	C16H20N2O
Molecular Weight	256.35 g/mol
Synonyms	(9R)-9-(2-Pyridinyl)-6-oxaspiro[4.5]decane-9-acetonitrile; (R)-2-(9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile; 2-((9R)-9-(Pyridin-2-yl)-6-oxaspiro[4.5]decan-9-yl)acetonitrile; 1401031-38-6; 2-[(9R)-9-(2-Pyridinyl)-6-oxaspiro[4.5]decan-9-yl]ethanenitrile; Spiro[4.5]decane-9-acetonitrile, 9-(2-pyridinyl)-6-oxa-, (9R)-
EINECS	Contact for details

Quality Control

Our 2-[(9R)-9-(Pyridin-2-Yl)-6-Oxaspiro[4.5]Decan-9-Yl]Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.