Description

2-Hydroxyethylflurazepam-D4 is a deuterated analog of a key benzodiazepine metabolite, specifically designed for use as an internal standard in analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in forensic toxicology and pharmaceutical research. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in method development, drug metabolism studies, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of flurazepam and its metabolites in biological matrices like plasma, serum, and urine.
• Forensic Toxicology: Used in the analysis of post-mortem samples and DUID (Driving Under the Influence of Drugs) cases to ensure legally defensible results.
• Pharmacokinetic Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for benzodiazepine-based drug products.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and validating test methods.
• Research & Development: Facilitates stable isotope dilution analysis in novel method development for benzodiazepine detection.

Basic Information

Product Name	2-Hydroxyethylflurazepam-D4
CAS No.	1397209-35-6
Molecular Formula	C₂₁H₂₀D₄ClFN₃O₃
Molecular Weight	425.91 g/mol (deuterated form)
Synonyms	7-Chloro-1-(2-(deuteriooxy)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-d3; Flurazepam D4 Metabolite; Flurazepam-d4 Hydroxyethyl Analog; 1,4-Benzodiazepin-2-one, 7-chloro-1-[2-(deuteriooxy)ethyl]-5-(2-fluorophenyl)-1,3-dihydro-, d3-; Deuterated 2-Hydroxyethylflurazepam; [D4]-2-Hydroxyethylflurazepam; Flurazepam N1-Hydroxyethyl-D4 Metabolite
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxyethylflurazepam-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic purity (≥98 atom % D), and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.