Description

3-(11-Amino-3,6,9-Trioxaundecanoxy)Benzoic Acid Methyl Ester Trifluoracetic Acid Salt is a specialized bifunctional PEG linker compound designed for advanced bioconjugation and pharmaceutical development. This high-purity intermediate is critical for researchers and manufacturers requiring precise, stable, and reproducible coupling reactions. It is primarily utilized in the synthesis of antibody-drug conjugates (ADCs), peptide modifications, and the development of targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key heterobifunctional crosslinker, connecting cytotoxic payloads to monoclonal antibodies via its amine and ester functional groups.
• PEGylation Reagent: Used to modify peptides, proteins, and small molecule drugs to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Acts as a flexible spacer element in the construction of heterobifunctional molecules for targeted protein degradation.
• Diagnostic Agent Conjugation: Facilitates the attachment of imaging agents (e.g., fluorophores, radiolabels) to targeting vectors like antibodies or peptides.
• Polymer and Dendrimer Chemistry: Employed as a building block for creating functionalized polymers with tailored properties for biomedical applications.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and other material surfaces with bioactive molecules.

Basic Information

Product Name	3-(11-Amino-3,6,9-Trioxaundecanoxy)Benzoic Acid Methyl Ester Trifluoracetic Acid Salt
CAS No.	1397189-87-5
Molecular Formula	C18H26F3NO8 • C2HF3O2 (or C20H27F6NO10)
Molecular Weight	~579.43 g/mol (as TFA salt)
Synonyms	3-(11-Amino-3,6,9-trioxaundecan-1-yloxy)benzoic acid methyl ester TFA salt; Methyl 3-(11-amino-3,6,9-trioxaundecyloxy)benzoate trifluoroacetate; Amino-PEG3-acid methyl ester TFA salt; mPEG3-NH2 Methyl Ester TFA Salt; 3-(2-[2-(2-Aminoethoxy)ethoxy]ethoxy)benzoic acid methyl ester TFA salt; Heterobifunctional PEG linker, Amine-PEG3-Methyl Ester TFA; AD-PEG3-ME TFA
EINECS	Contact for details

Quality Control

Our 3-(11-Amino-3,6,9-Trioxaundecanoxy)Benzoic Acid Methyl Ester Trifluoracetic Acid Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to minimize moisture absorption. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.