Description

(2R)-2-(Trifluoromethyl)Morpholine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in the trifluoromethyl group, which is a key motif for enhancing the metabolic stability, lipophilicity, and bioavailability of active pharmaceutical ingredients. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on synthesizing novel therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group imparts improved biological activity.
• Organofluorine Chemistry Research: Serves as a valuable reagent for studying the introduction and effects of fluorine atoms in organic molecules.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands and catalysts for asymmetric synthesis applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	(2R)-2-(Trifluoromethyl)Morpholine Hydrochloride
CAS No.	1394909-70-6
Molecular Formula	C5H9F3NO • HCl
Molecular Weight	195.59 g/mol (Free base: 155.13 g/mol)
Synonyms	(R)-2-(Trifluoromethyl)morpholine hydrochloride; (2R)-2-(Trifluoromethyl)-4-morpholinyl hydrochloride; Morpholine, 2-(trifluoromethyl)-, hydrochloride, (2R)-; (R)-2-Trifluoromethylmorpholine HCl; (R)-2-(Trifluoromethyl)morpholine HCl salt; (R)-TFM-Morpholine HCl; (2R)-α-(Trifluoromethyl)-4-morpholineethanol hydrochloride (related); Enantiomerically pure 2-trifluoromethylmorpholine HCl
EINECS	Contact for details

Quality Control

Our (2R)-2-(Trifluoromethyl)Morpholine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR, and LC-MS for identity and impurity profiling, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.