Description

(R)-2-(1-Amino-2,2,2-Trifluoroethyl)Phenol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its value lies in its unique trifluoroethylamine-phenol structure, which is critical for imparting specific biological activity and metabolic stability to advanced drug candidates. This compound is essential for research and development teams in the pharmaceutical and agrochemical industries, particularly those focused on synthesizing novel active ingredients for central nervous system (CNS) disorders, oncology, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in CNS-targeting drugs.
• Agrochemical Research: Used as a building block for developing advanced herbicides and pesticides with enhanced efficacy.
• Asymmetric Synthesis: Serves as a valuable precursor for creating complex, enantiomerically pure molecules in medicinal chemistry.
• Ligand & Catalyst Development: Employed in the research and preparation of chiral ligands and organocatalysts for stereoselective reactions.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Investigated as a monomer or functional additive for specialty polymers with unique optical or electronic properties.

Basic Information

Product Name	(R)-2-(1-Amino-2,2,2-Trifluoroethyl)Phenol Hydrochloride
CAS No.	1394822-90-2
Molecular Formula	C8H9ClF3NO
Molecular Weight	227.61 g/mol
Synonyms	(R)-2-(1-Amino-2,2,2-trifluoroethyl)phenol hydrochloride; (R)-2-(1-Amino-2,2,2-trifluoroethyl)phenol HCl; (R)-α-(Aminomethyl)-2-hydroxybenzyl alcohol hydrochloride, 2,2,2-trifluoro-; (R)-1-(2-Hydroxyphenyl)-2,2,2-trifluoroethanamine hydrochloride; (R)-2-Hydroxy-α-(trifluoromethyl)benzylamine hydrochloride; (R)-TFMPA HCl; (R)-Trifluoromethylphenylethanolamine hydrochloride (specific isomer)
EINECS	Contact for details

Quality Control

Our (R)-2-(1-Amino-2,2,2-Trifluoroethyl)Phenol Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing specifications for identity, purity (assay), enantiomeric excess, and related substances is provided with each shipment. We adhere to cGMP principles where applicable to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.