Description

2,7-Diazaspiro[4.4]Nonan-3-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its rigid, three-dimensional spirocyclic structure, which is crucial for modulating the physicochemical and biological properties of novel drug candidates. It is primarily sought after by research and development teams in the pharmaceutical and biotechnology sectors for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic scaffold.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme function and biological pathways.
• Agrochemical Research: Investigated as a precursor for novel compounds with potential herbicidal or insecticidal activity.
• Academic & Contract Research: Supplied to universities and CROs for fundamental organic synthesis research and custom synthesis projects.

Basic Information

Product Name	2,7-Diazaspiro[4.4]Nonan-3-One Hydrochloride
CAS No.	1393330-70-5
Molecular Formula	C7H13N2O·HCl
Molecular Weight	176.65 g/mol
Synonyms	2,7-Diazaspiro[4.4]nonan-3-one, hydrochloride; 3-Oxo-2,7-diazaspiro[4.4]nonane hydrochloride; 2,7-Diazaspiro[4.4]nonane-3-one HCl; Spiro[4.4]nonane-3-one, 2,7-diaza-, hydrochloride; 1393330-70-5; 2,7-Diazaspiro[4.4]nonan-3-one monohydrochloride
EINECS	Contact for details

Quality Control

Our 2,7-Diazaspiro[4.4]Nonan-3-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.