Description

[3,5-Difluoro-4-(Oxan-4-Ylmethoxy)Phenyl]Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its distinct fluorinated aromatic structure. This compound is of significant value in modern medicinal chemistry for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting protein kinases and other enzymes.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved potency and pharmacokinetic profiles.
• API Development: Serves as a key scaffold for constructing final active pharmaceutical ingredients, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and membrane permeability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Bioconjugation & Probe Synthesis: The amine hydrochloride group enables its use in creating fluorescent probes, affinity labels, or antibody-drug conjugates (ADCs) for diagnostic and therapeutic applications.

Basic Information

Product Name	[3,5-Difluoro-4-(Oxan-4-Ylmethoxy)Phenyl]Methanamine Hydrochloride
CAS No.	1393330-45-4
Molecular Formula	C13H18ClF2NO2
Molecular Weight	293.74 g/mol
Synonyms	4-(Tetrahydropyran-4-ylmethoxy)-3,5-difluorobenzylamine hydrochloride; (3,5-Difluoro-4-((tetrahydro-2H-pyran-4-yl)methoxy)phenyl)methanamine hydrochloride; 3,5-Difluoro-4-((tetrahydropyran-4-yl)methoxy)benzylamine HCl; 4-((Oxan-4-yl)methoxy)-3,5-difluorophenylmethanamine hydrochloride; Benzylamine, 3,5-difluoro-4-((tetrahydro-2H-pyran-4-yl)methoxy)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our [3,5-Difluoro-4-(Oxan-4-Ylmethoxy)Phenyl]Methanamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.