Description

(Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid-Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is critical for the synthesis of complex molecules, offering a versatile chiral building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on creating new active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a crucial building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Used in the construction of complex, stereochemically defined molecules due to its trans-configured pyrrolidine carboxylic acid scaffold.
• Preclinical & Clinical Trial Material: Supplied under controlled conditions for the synthesis of compounds used in non-clinical and clinical studies.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	(Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid Hydrochloride
CAS No.	1392210-72-8
Molecular Formula	C13H18ClNO4
Molecular Weight	287.74 g/mol
Synonyms	(3R,4S)-4-(3,4-Dimethoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride; (3R,4S)-1-(3,4-Dimethoxyphenyl)-3-carboxypyrrolidine hydrochloride; trans-4-(3,4-Dimethoxyphenyl)pyrrolidine-3-carboxylic acid HCl; (3R,4S)-4-(3,4-Dimethoxyphenyl)-3-pyrrolidinecarboxylic acid hydrochloride; 1392210-72-8; (3R,4S)-4-(3,4-Dimethoxy-phenyl)-pyrrolidine-3-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our (Trans)-4-(3,4-Dimethoxy-Phenyl)-Pyrrolidine-3-Carboxylic Acid-Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development with custom purity grades and specifications aligned with current Good Manufacturing Practice (cGMP) principles for investigational products.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.