Description

(R)-2-(2-Chloro-5-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride is a high-purity chiral intermediate and building block of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and functionalized aromatic-pyrrolidine scaffold, which is crucial for constructing molecules with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of potential new drug candidates, particularly in central nervous system (CNS) and other therapeutic areas.
• Agrochemical Synthesis: Used as a building block for creating advanced, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Research: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and protein interactions.
• Material Science Research: Potential precursor for specialty polymers or advanced organic materials requiring specific chiral motifs.
• Custom Synthesis and Scale-Up: Supplied for contract research and manufacturing projects requiring this specific enantiomer for process development and optimization.

Basic Information

Product Name	(R)-2-(2-Chloro-5-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride
CAS No.	1391519-06-4
Molecular Formula	C11H11ClF3N • HCl
Molecular Weight	286.57 g/mol (Free base: 249.66 g/mol)
Synonyms	(R)-2-(2-Chloro-5-(trifluoromethyl)phenyl)pyrrolidine hydrochloride; (R)-2-(2-Chloro-alpha,alpha,α-trifluoro-p-tolyl)pyrrolidine hydrochloride; (R)-2-[2-Chloro-5-(trifluoromethyl)phenyl]pyrrolidine hydrochloride; (R)-2-(2-Chloro-5-(trifluoromethyl)phenyl)pyrrolidine HCl; (R)-2-(2-Chloro-5-(trifluoromethyl)phenyl)-1-pyrrolidine hydrochloride; (R)-2-(2-Chloro-5-(trifluoromethyl)phenyl)azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(2-Chloro-5-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.