Description

3-Methoxy-D-Phenylalanine Methyl Ester Hcl is a protected, non-natural amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block for the construction of complex peptides and peptidomimetics with enhanced metabolic stability. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate methoxy-substituted phenylalanine residues, modifying peptide properties.
• Protease Inhibitor Development: Serves as a core structural element in designing inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and signal transduction pathways.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality.
• Reference Standard: Sourced for analytical purposes as a high-purity standard for method development and quality control in regulatory submissions.

Basic Information

Product Name	3-Methoxy-D-Phenylalanine Methyl Ester Hcl
CAS No.	1391507-80-4
Molecular Formula	C11H15NO3 • HCl
Molecular Weight	245.70 (Free base) / 282.16 (HCl salt)
Synonyms	D-3-Methoxyphenylalanine Methyl Ester Hydrochloride; Methyl (R)-2-amino-3-(3-methoxyphenyl)propanoate hydrochloride; (R)-Methyl 2-amino-3-(3-methoxyphenyl)propanoate hydrochloride; Methyl D-3-Methoxy-phenylalaninate HCl; D-3-Methoxy-Phe-OMe • HCl; (R)-3-Methoxy-phenylalanine methyl ester hydrochloride; 3-Methoxy-D-Phe-OMe • HCl
EINECS	Contact for details

Quality Control

Our 3-Methoxy-D-Phenylalanine Methyl Ester Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.