Description

(1R)-1-(2,6-Dichlorophenyl)Propan-1-Amine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and analgesic drug candidates. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in process development and scale-up of novel therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel analgesic and neuroactive drug candidates.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies during drug discovery.
• Process Chemistry: Serves as a starting material or intermediate in the development and optimization of scalable API manufacturing routes.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Item	Detail
Product Name	(1R)-1-(2,6-Dichlorophenyl)Propan-1-Amine Hydrochloride
CAS No.	1391503-15-3
Molecular Formula	C9H10Cl2N • HCl
Molecular Weight	240.55 g/mol (Free base: 204.09 g/mol)
Synonyms	(1R)-1-(2,6-Dichlorophenyl)propan-1-amine hydrochloride; (R)-1-(2,6-Dichlorophenyl)propan-1-amine HCl; (R)-2,6-Dichloro-α-propylbenzenemethanamine hydrochloride; Dexchlorpheniramine related amine; (R)-1-Amino-1-(2,6-dichlorophenyl)propane hydrochloride; (R)-1-(2,6-Dichlorophenyl)-1-aminopropane hydrochloride; (R)-Norchlorpheniramine precursor
EINECS	Contact for details

Quality Control

Our (1R)-1-(2,6-Dichlorophenyl)Propan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, to ensure it meets the high standards required for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.