Description

[4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in the incorporation of a stereodefined pyrrolidine moiety and a trifluoromethoxy group, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis or as a scaffold for enzyme inhibitors in medicinal chemistry.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Investigated as a component in specialty polymers or advanced organic materials due to its unique structural features.

Basic Information

Product Name	[4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane Hydrochloride
CAS No.	1391490-20-2
Molecular Formula	C11H13F3NO•HCl
Molecular Weight	267.68 g/mol (Free base: 231.22 g/mol)
Synonyms	(R)-4-(2-Pyrrolidinyl)phenoxy trifluoromethane hydrochloride; (2R)-2-[4-(Trifluoromethoxy)phenyl]pyrrolidine hydrochloride; 4-[(2R)-Pyrrolidin-2-yl]phenyl trifluoromethyl ether hydrochloride; Trifluoromethoxy-(R)-2-(4-pyrrolidin-2-yl-phenoxy) hydrochloride; (R)-α-(4-Trifluoromethoxyphenyl)pyrrolidine HCl
EINECS	Contact for details

Quality Control

Our [4-((2R)Pyrrolidin-2-Yl)Phenoxy]Trifluoromethane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) that include chiral purity, assay, and impurity profiles, meeting the stringent requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.