Description

(R)-1-(3-Chlorophenyl)-2-Methylpropan-1-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical pharmaceutical intermediate and research chemical. Its value lies in its defined stereochemistry and high chemical purity, which are essential for ensuring the efficacy and safety of final active pharmaceutical ingredients (APIs). This compound is primarily needed by pharmaceutical R&D teams, process chemists, and manufacturers engaged in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and other specialty drug development pipelines.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs) for preclinical and clinical development.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development and optimization of scalable, GMP-compliant manufacturing routes.
• Reference Standard: Utilized as an analytical standard for quality control, method development, and regulatory submissions.
• Biochemical Research: Investigated for its potential biological activity and interaction with various enzymes or receptors in biochemical assays.

Basic Information

Product Name	(R)-1-(3-Chlorophenyl)-2-Methylpropan-1-Amine Hydrochloride
CAS No.	1391479-99-4
Molecular Formula	C10H14ClN•HCl
Molecular Weight	220.14 g/mol (Free base: 183.68 g/mol)
Synonyms	(R)-1-(3-Chlorophenyl)-2-methylpropylamine hydrochloride; (R)-3-Chloro-α-isobutylbenzylamine hydrochloride; (R)-1-Amino-2-methyl-1-(3-chlorophenyl)propane hydrochloride; (R)-1-(3-Chlorophenyl)-2-methyl-1-propanamine hydrochloride; (R)-3-Chloro-α-isobutylbenzylamine HCl; (R)-1-(3-Chlorophenyl)-2-methylpropylamine HCl; (R)-3-Chlorophenylisobutylamine hydrochloride; (R)-CPIB amine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-1-(3-Chlorophenyl)-2-Methylpropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity (typically >98.0%), chiral excess (>99.0% ee), and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.