Description

(R)-2,2,2-Trifluoro-1-(o-Tolyl)Ethanamine Hcl is a high-purity chiral amine building block, specifically the hydrochloride salt of the (R)-enantiomer. This compound is a critical intermediate in the synthesis of advanced pharmaceutical molecules, particularly those requiring a trifluoromethylated chiral center for enhanced metabolic stability and bioavailability. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for your process development and scale-up needs.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel APIs, especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Research: Used in developing advanced herbicides and pesticides where the trifluoromethyl group and chiral specificity influence biological activity.
• Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in asymmetric synthesis.
• Peptidomimetics: Incorporated into peptide analogs to modulate stability, lipophilicity, and receptor binding profiles.
• Material Science: Potential monomer or additive for specialty polymers with unique optical or surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and protein interactions.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(o-Tolyl)Ethanamine Hydrochloride
CAS No.	1391475-10-7
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	(R)-1-(2-Methylphenyl)-2,2,2-trifluoroethanamine hydrochloride; (R)-α-Methylbenzylamine, 2,2,2-trifluoro-, hydrochloride; (R)-2,2,2-Trifluoro-1-(2-methylphenyl)ethan-1-amine hydrochloride; (R)-o-Methyl-α-(trifluoromethyl)benzylamine hydrochloride; (R)-1-(o-Tolyl)-2,2,2-trifluoroethylamine HCl; (R)-TFMBA HCl; (R)-Trifluoro-o-tolylethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(o-Tolyl)Ethanamine HCl is manufactured under strict quality management systems. Every batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.