Description

(3S)-3-(4-Fluorophenyl)Morpholine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its role in the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily sought by research institutions, contract research and manufacturing organizations (CROs/CMOs), and pharmaceutical companies developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the (3S)-3-(4-fluorophenyl)morpholine scaffold into candidate molecules.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate for the pilot-scale and commercial-scale synthesis of advanced APIs.
• Asymmetric Synthesis: Employed in chiral pool synthesis and as a precursor for other enantiomerically pure compounds due to its defined stereochemistry.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Detail
Product Name	(3S)-3-(4-Fluorophenyl)Morpholine Hydrochloride
CAS No.	1391469-10-5
Molecular Formula	C10H13ClFNO
Molecular Weight	217.67 g/mol
Synonyms	(3S)-3-(4-Fluorophenyl)morpholine HCl; (S)-3-(4-Fluorophenyl)morpholine hydrochloride; (S)-3-(p-Fluorophenyl)morpholine hydrochloride; (3S)-3-(4-Fluorophenyl)-tetrahydro-2H-1,4-oxazine hydrochloride; 3-(4-Fluorophenyl)morpholine hydrochloride (S-enantiomer); (S)-(-)-3-(4-Fluorophenyl)morpholine hydrochloride; 1391469-10-5; (S)-3-(4-Fluorophenyl)morpholine HCl salt
EINECS	Contact for details

Quality Control

Our (3S)-3-(4-Fluorophenyl)Morpholine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) and spectroscopic characterization are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.