Description

(S)-2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride is a high-purity chiral amine building block of significant importance in advanced pharmaceutical synthesis. Its core value lies in providing a trifluoromethylated, enantiomerically pure scaffold that is critical for modulating the pharmacokinetic and metabolic properties of drug candidates. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced bioavailability and stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the research and production of advanced, enantiomerically pure pesticides and herbicides, where the (S)-configuration can be crucial for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Compound Research: An important building block in medicinal chemistry for introducing the trifluoromethyl group, a common motif used to improve metabolic stability and membrane permeability.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride
CAS No.	1391468-35-1
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	(S)-1-(3-Methylphenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-α-Methyl-3-(trifluoromethyl)benzylamine hydrochloride; (S)-1-(m-Tolyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-2,2,2-Trifluoro-1-(3-methylphenyl)ethanamine hydrochloride; (S)-m-Tolyl-α-(trifluoromethyl)methylamine hydrochloride; (S)-1-(3-Methylphenyl)-2,2,2-trifluoroethan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-m-Tolyl-Ethylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.