Description

(2R)-2-Amino-2-[4-(Methylethyl)Phenyl]Ethan-1-Ol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its defined stereochemistry and functional groups make it a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical and agrochemical sectors seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and cardiovascular drug discovery.
• Asymmetric Synthesis: Utilized as a building block in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with specific chiral activity.
• Catalyst and Ligand Development: Used in the preparation of chiral catalysts and ligands for homogeneous catalysis applications.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	(2R)-2-Amino-2-[4-(Methylethyl)Phenyl]Ethan-1-Ol Hydrochloride
CAS No.	1391467-74-5
Molecular Formula	C11H17NO • HCl
Molecular Weight	215.72 g/mol (Free base: 179.26 g/mol)
Synonyms	(R)-2-Amino-2-(4-isopropylphenyl)ethanol hydrochloride; (R)-1-(4-Isopropylphenyl)-2-aminoethanol hydrochloride; (2R)-2-Amino-2-(4-propan-2-ylphenyl)ethan-1-ol hydrochloride; (R)-Hordenine precursor hydrochloride; p-Isopropylphenylethanolamine, (R)-, hydrochloride; 4-(1-Methylethyl)-benzenemethanol, α-amino-, (αR)-, hydrochloride; (R)-α-Amino-4-isopropylbenzenemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (2R)-2-Amino-2-[4-(Methylethyl)Phenyl]Ethan-1-Ol Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing chiral purity (enantiomeric excess), assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition (Sulfated Ash)	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.