Description

(S)-2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride is a high-purity chiral amine building block essential for modern pharmaceutical synthesis. Its value lies in providing a key trifluoromethylated and chlorinated pharmacophore, enabling the development of novel bioactive molecules with enhanced metabolic stability and binding affinity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-infective therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Agrochemical Research: Used in developing advanced pesticides and herbicides where the trifluoromethyl group imparts improved lipophilicity and biological activity.
• Asymmetric Catalysis: Serves as a chiral ligand precursor or a resolving agent in asymmetric synthetic transformations.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorination and chlorination on drug-like properties.
• Process Chemistry: Used in scaling up routes for the production of complex molecules requiring this specific enantiomer.
• Chemical Biology: Acts as a molecular probe for studying enzyme mechanisms or receptor interactions due to its fluorine atoms (potential 19F NMR label).

Basic Information

Product Name	(S)-2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride
CAS No.	1391426-98-4
Molecular Formula	C8H8ClF3N • HCl
Molecular Weight	250.51 g/mol
Synonyms	(S)-1-(3-Chlorophenyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-α-(3-Chlorophenyl)-2,2,2-trifluoroethylamine HCl; (S)-3-Chloro-α-(trifluoromethyl)benzylamine hydrochloride; (1S)-1-[3-Chlorophenyl]-2,2,2-trifluoroethanaminium chloride; (S)-1-(3-Chloro-phenyl)-2,2,2-trifluoro-ethylamine hydrochloride; (S)-TFMPA HCl (3-Chloro); (S)-Enantiomer of 3-Chloro-α,α,α-trifluorophenethylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-(3-Chloro-Phenyl)-Ethylamine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Production adheres to cGMP guidelines where applicable. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.