Description

(R)-2-(2-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and the unique properties imparted by the trifluoromethylphenyl group, which is crucial for modulating the biological activity and metabolic stability of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates.
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereocenters in medicinal chemistry.
• Chemical Research: Employed in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new synthetic methodologies.
• Ligand & Catalyst Development: Potential precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-(2-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride
CAS No.	1391384-41-0
Molecular Formula	C11H12F3N•HCl
Molecular Weight	251.68 g/mol (Free base: 215.22 g/mol)
Synonyms	(R)-2-[2-(Trifluoromethyl)phenyl]pyrrolidine hydrochloride; (R)-2-(2-Trifluoromethylphenyl)pyrrolidine HCl; (R)-α-(2-Trifluoromethylphenyl)-2-pyrrolidinemethane hydrochloride; (R)-2-(α,α,α-Trifluoro-o-tolyl)pyrrolidine hydrochloride; (R)-NSC 390218 hydrochloride; (R)-Trifluoromethylphenylpyrrolidine HCl
EINECS	Contact for details

Quality Control

Our (R)-2-(2-(Trifluoromethyl)Phenyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.