Description

(2S)-2-Amino-2-(2-Chloro-4-Fluorophenyl)Ethan-1-Ol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, particularly those focused on creating novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, leveraging the chloro-fluorophenyl moiety for bioactivity.
• Chemical Research & Development: Used as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale synthesis for the commercial manufacturing of complex organic molecules.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in enantioselective catalytic reactions to construct stereogenic centers.

Basic Information

Product Name	(2S)-2-Amino-2-(2-Chloro-4-Fluorophenyl)Ethan-1-Ol Hydrochloride
CAS No.	1391376-63-8
Molecular Formula	C8H10Cl2FNO
Molecular Weight	234.08 g/mol
Synonyms	(2S)-2-Amino-2-(2-Chloro-4-fluorophenyl)ethanol hydrochloride; (S)-2-Amino-2-(2-chloro-4-fluorophenyl)ethanol HCl; 2-Chloro-4-fluoro-D-phenylglycinol hydrochloride; (S)-2-Amino-2-(2-chloro-4-fluorophenyl)ethan-1-ol hydrochloride; (S)-2-(2-Chloro-4-fluorophenyl)-2-aminoethanol hydrochloride; D-2-Amino-2-(2-chloro-4-fluorophenyl)ethanol hydrochloride; (S)-2-(2-Chloro-4-fluorophenyl)glycinol hydrochloride
EINECS	Contact for details

Quality Control

Our (2S)-2-Amino-2-(2-Chloro-4-Fluorophenyl)Ethan-1-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.