Description

(S)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride is a high-purity chiral amine building block, specifically the hydrochloride salt of the (S)-enantiomer. This compound is valued for its trifluoromethyl group and chiral center, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of advanced pharmaceutical candidates. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fine-tuned molecular properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the chiral specificity and fluorine content can enhance efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective synthesis.
• Material Science: Investigated as a monomer or additive for specialty polymers, where the fluorine atoms can impart unique surface properties and chemical resistance.
• Diagnostic Reagent Synthesis: Employed in the creation of chiral probes and labeling agents for biochemical assays and imaging.

Basic Information

Item	Details
Product Name	(S)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride
CAS No.	1391361-49-1
Molecular Formula	C9H11ClF3N
Molecular Weight	225.64 g/mol
Synonyms	(S)-1-(4-Methylphenyl)-2,2,2-trifluoroethylamine hydrochloride; (S)-α-(Trifluoromethyl)-4-methylbenzylamine hydrochloride; (S)-1-(p-Tolyl)-2,2,2-trifluoroethanamine hydrochloride; (S)-2,2,2-Trifluoro-1-(4-methylphenyl)ethanamine hydrochloride; (S)-TFMA HCl; (S)-Trifluoro-p-tolylethylamine HCl; (S)-1-(4-Methylphenyl)-2,2,2-trifluoroethanaminium chloride
EINECS	Contact for details

Quality Control

Our (S)-2,2,2-Trifluoro-1-p-Tolyl-Ethylamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.