Description

(2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(2-Fluorophenyl)-2-Methylpropanoic Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a fluorinated aromatic side chain, making it a critical building block for advanced pharmaceutical research. Its primary value lies in enabling the synthesis of complex, biologically active peptides and small molecules with enhanced metabolic stability and binding affinity. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for developing novel therapeutics targeting central nervous system disorders and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Peptidomimetic Synthesis: Used to incorporate a fluorinated, non-natural amino acid residue into peptide chains to improve proteolytic stability and membrane permeability.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various enzyme targets due to its specific stereochemistry and fluorophenyl group.
• Chemical Biology & Probe Design: Employed in the creation of labeled or tagged molecular probes for studying protein-protein interactions and biological pathways.
• Process Chemistry & Scale-Up: Provides a defined chiral starting material for optimizing synthetic routes during late-stage process development and manufacturing.
• Academic Research: Utilized in university and institutional labs for methodological studies in asymmetric synthesis and fluorine chemistry.

Basic Information

Product Name	(2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(2-Fluorophenyl)-2-Methylpropanoic Acid
CAS No.	1389316-08-8
Molecular Formula	C15H20FNO4
Molecular Weight	297.32 g/mol
Synonyms	Boc-2-Fluoro-D-β-methylphenylalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3-(2-fluorophenyl)-2-methylpropanoic Acid; Boc-(R)-β-Me-2-F-Phe-OH; N-Boc-3-(2-Fluorophenyl)-D-β-methylalanine; N-(tert-Butoxycarbonyl)-3-(2-fluorophenyl)-D-β-methylalanine; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(2-fluorophenyl)-2-methylpropanoic Acid; 2-Fluoro-D-β-methylphenylalanine Boc derivative
EINECS	Contact for details

Quality Control

Our production of (2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-3-(2-Fluorophenyl)-2-Methylpropanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.