Description

4,4-Difluoro-1-[(3-Fluorophenyl)Methyl]Cyclohexan-1-Amine Hydrochloride is a high-purity, fluorinated organic building block of significant interest in advanced pharmaceutical research and development. This compound matters as a critical intermediate for synthesizing novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas where its specific fluorine-substituted cyclohexylamine scaffold is valuable. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the discovery and process development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up API synthesis for clinical trials.
• Library Synthesis for High-Throughput Screening: Employed to create focused chemical libraries for biological screening against various disease targets.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the effects of strategic fluorine substitution on molecular conformation and bioactivity.

Basic Information

Product Name	4,4-Difluoro-1-[(3-Fluorophenyl)Methyl]Cyclohexan-1-Amine Hydrochloride
CAS No.	1389315-20-1
Molecular Formula	C13H17ClF3N
Molecular Weight	279.73 g/mol
Synonyms	1-[(3-Fluorophenyl)methyl]-4,4-difluorocyclohexan-1-amine hydrochloride; 4,4-Difluoro-1-[(3-fluorobenzyl)]cyclohexanamine hydrochloride; 1-(3-Fluorobenzyl)-4,4-difluorocyclohexan-1-amine HCl; 4,4-Difluoro-1-(3-fluorobenzyl)cyclohexanamine hydrochloride; 1389315-20-1; 4,4-Difluoro-1-[(3-fluorophenyl)methyl]cyclohexanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-[(3-Fluorophenyl)Methyl]Cyclohexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment and allowed to reach ambient temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.