Description

4,4-Difluoro-1-Methylcyclohexan-1-Amine Hydrochloride is a high-purity, functionalized cyclohexylamine derivative. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block for the synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to introduce a fluorinated, sterically defined amine moiety.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the difluoro and amine groups contribute to biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic frameworks where fluorination alters material properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4,4-Difluoro-1-Methylcyclohexan-1-Amine Hydrochloride
CAS No.	1389313-43-2
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	1-Amino-4,4-difluoro-1-methylcyclohexane hydrochloride; 1-Methyl-4,4-difluorocyclohexylamine hydrochloride; 4,4-Difluoro-1-methyl-1-cyclohexanamine hydrochloride; 4,4-Difluoro-N-methylcyclohexanamine hydrochloride; 1-Methyl-4,4-difluorocyclohexanamine HCl; 4,4-Difluoro-1-methylcyclohexanamine HCl salt
EINECS	Contact for details

Quality Control

Every batch of 4,4-Difluoro-1-Methylcyclohexan-1-Amine Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity requirements for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports applications requiring material traceability and consistent performance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.