Description

5-(Boc-Amino)Thiazole-2-Carboxylic Acid is a high-purity, protected amino acid derivative featuring a thiazole heterocycle, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the controlled synthesis of complex peptides and bioactive molecules, where the Boc (tert-butoxycarbonyl) group provides orthogonal protection for the amine functionality. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting infectious diseases or metabolic disorders.
• Peptide Synthesis: Used as a protected amino acid analog in solid-phase and solution-phase peptide synthesis to construct thiazole-containing peptide sequences.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and plant growth regulators with novel modes of action.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes, enzyme inhibitors, and molecular tools for studying biological pathways.
• Material Science: A monomer for creating specialized polymers and functionalized surfaces with unique electronic or binding properties.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis projects and library production for high-throughput screening.

Basic Information

Product Name	5-(Boc-Amino)Thiazole-2-Carboxylic Acid
CAS No.	1389264-14-5
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-1,3-thiazole-2-carboxylic acid; 2-Thiazolecarboxylic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-; 5-(tert-Butoxycarbonylamino)thiazole-2-carboxylic acid; Boc-5-Amino-2-thiazolecarboxylic acid; 5-(Boc-amino)-2-thiazolecarboxylic acid; 5-(Boc-NH)-thiazole-2-COOH; (5-((tert-Butoxycarbonyl)amino)thiazol-2-yl)formic acid
EINECS	Contact for details

Quality Control

Our 5-(Boc-Amino)Thiazole-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with customer specifications. We support development and commercial projects requiring ICH stability data and can supply material manufactured under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.